Unconventional stop codons in the mitochondrial genome were thought to be recognized by the mitochondrial release factors mtRF1 and mtRF1a. Here, Lind et al.employ homology modelling and ...

Scientists sought to work out genetic errors by creating their own artificial genome, which replaced E. coli’s original genome and used less genetic material.

Research led by Duke University, Durham, has discovered a situation-dependent traffic jam in mRNA translation caused by RNA hairpins leading to higher translation of upstream start codons (uAUGs).